Target marketing, yup, you remember that stuff your marketing professor went on and on about. The Canadian Tourism Commission (why is there no U.S. counterpart?) has this cool site call Clever Women targeting female, German travelers. The site is in German, translate here.
A pretty cool concept, with some Web 2.0 features. Not sure if every destination marketing organization has the resources to do this, but if you wanted to focus, this is the way.